Dignify Therapeutics


Alexander M, Bashir K, Alexander C, Marson L, Rosen R.  A randomized trial of clitoral vacuum suction and vibratory stimulation in neurogenic female orgasmic dysfunction. Archives of Physical Medicine and Rehabilitation. 2017 Sep 9. doi: 10.1016/j.apmr.2017.09.001.

Alexander MS, Marson LThe neurologic control of arousal and orgasm with specific attention to spinal cord lesions: Integrating preclinical and clinical sciences.Autonomic Neuroscience: Basic and Clinical Jan 25. doi: 10.1016/j.autneu.2017.01.005.

Kullmann FA, Katofiasc M, Thor KB, Marson, L.  Pharmacodynamic evaluation of Lys5, MeLeu9, Nle10­NKA(4–10) prokinetic effects on bladder and colon activity in acute spinal cord transected and spinally intact rats. Naunyn­-Schmiedeberg’s Arch Pharmacol. 2017 Feb;390(2):163­173. PMID: 27889808.

Kullmann FA, Kurihara R, Ye L, Wells GI, McKenna DG, Burgard EC, Thor KB.  Effects of the 5-HT4 receptor agonist, cisapride, on neuronally evoked responses in human bladder, urethra, and ileum. Auton Neurosci. 2013 Jun;176(1-2):70-7.  PMID: 23511063.

Burgard EC, Fraser MO, Karicheti V, Ricca DJ, Thor KB. New pharmacological treatments for urinary incontinence and overactive bladder. Curr Opin Investig Drugs. 2005 Jan;6(1):81-9.  PMID: 15675607.

deGroat WC, Kawatani M, Hisamitsu T, Cheng CL, Ma CP, Thor KB, Steers W, Roppolo JR:  Mechanisms underlying the recovery of urinary bladder function following spinal cord injury.  J Autonom Nerv Syst 30: S71-S78, 1990. PMID:  2212495.

Thor KB, Roppolo JR, Kawatani M, Erdman S, deGroat WC:  Plasticity in spinal opioid control of lower urinary tract function in paraplegic cats.  Neurorept  5: 1673-1678, 1994. PMID:  7819545.

Thor KB, Katofiasc MAEffects of duloxetine a combined serotonin and norepinephrine re-uptake inhibitor on central neural control of lower urinary tract function in the chloralose-anesthetized female cat.  J Pharmacol Exp Ther 274: 1014-1024, 1995. PMID:  7636716.

Ashburn TT, Thor KB: Drug repositioning: identifying and developing new uses for existing drugs.  Nature Reviews. Drug Discovery 3:673-83, 2004. PMID: 15286734.

Gu B, Olejar KJ, Reiter JP, Thor KB, Dolber PC: Inhibition of bladder activity by 5-HT1 serotonin receptor agonists in cats with chronic spinal cord injury.  J. Pharmacol. Expt. Ther. 310: 1266-72, 2004. PMID:  15152026.

Thor KB, de Groat WC: Neural control of the female urethral and anal rhabdosphincter and pelvic floor muscles.  Am. J. Physiol. Regul. Integr. Comp. Physiol.  299:R416-R438, 2010. PMID:   20484700.

Karicheti V, Langdale CL, Ukai M, Thor KB: Characterization of a “Spinal – Urine Storage Reflex – Inhibitory Center” (SUSRIC) and Its Regulation by Serotonin 5-HT1A Receptors in Female Cats. Am J Physiol Regul Integr Comp Physiol. 298: R1198-R1208, 2010. PMID:  20164207.

Karicheti V, Christ GJ. Physiological roles for K+ channels and gap junctions in urogenital smooth muscle: Implications for improved understanding of urogenital function, disease and therapy. Current Drug Targets. 2, 1-20, 2001. PMID: 11465535.

Marson, L. Spinal control of sexual reflexes: An overview of studies from animal models. Topics In Spinal Cord Rehabilitation. 8:42-50 (2002).

Looney, C., Thor, K.B., Ricca, D. and Marson, L. Differential effects of simultaneous or sequential administration of paroxetine and WAY-100,635 on ejaculatory behavior. Pharmacology Biochemistry and Behavior. 82:427-433 (2005). PMID 16253317.

Versi E, Cardozo LD, Studd JWW, Brincat M, O’Dowd TM, Cooper DJ (1986) Internal urinary sphincter in maintenance of female continence.  Br Med J 292, 166167.

Chapple C, Artibani W, Cardozo L, Castro-Diaz D, Craggs M, Haab F, Khullar V, Versi EThe role of urinary urgency and its measurement in the overactive bladder symptom syndrome: current concepts and future prospects.  BJU International, 2005; 95:335-340. PMID:   15679789.